Is Sarcopenia a Red Flag for Cognitive Decline After Menopause?
- Aesthetic Astute
- 1 day ago
- 3 min read
As we continue to learn more about the complex changes women experience after menopause, emerging research is revealing just how interconnected our physical and cognitive health truly are.
A recent study published in Maturitas by Vallejo et al. (2025) brings a fresh perspective to this discussion. It suggests that sarcopenia, the loss of muscle mass and strength, may not only impact mobility and physical resilience but could also signal an increased risk of cognitive decline in postmenopausal women.
What Did the Study Find?
The research was part of a larger study conducted by the REDLINC network (Research of the Climacteric in Latin America) involving over 1,100 women, with a focused sub-analysis on 772 postmenopausal women who had experienced natural menopause. The researchers used a simple screening tool called the SARC-F, designed to assess risk of sarcopenia, and compared it to outcomes on the MoCA test (Montreal Cognitive Assessment), which screens for mild cognitive impairment (MCI).
The results were significant:
Women at risk of sarcopenia (SARC-F score ≥4) were 2.44 times more likely to have MCI.
The prevalence of MCI jumped from 12.9% in women with no sarcopenia risk to 35.3% in those at risk.
Those with cognitive impairment were more likely to have a higher BMI, be physically inactive, and report more severe menopausal symptoms.
Importantly, protective factors included:
Higher educational attainment
Prior use of menopausal hormone therapy (MHT)
Why Does Sarcopenia Matter?
We’ve long understood the role of muscle mass in maintaining balance, bone strength, and mobility as we age. But this study highlights that loss of muscle strength may also be a warning sign of declining brain health. The postmenopausal period is already a time of increased risk for metabolic changes, inflammation, and hormonal shifts, all of which may accelerate both sarcopenia and cognitive decline if left unaddressed.
These findings aren’t isolated. Other studies, such as those by Maniscalco et al. (2024) and Dong et al. (2024), have also identified links between sarcopenia and reduced executive function, memory, and verbal fluency. Taken together, these insights support a more integrated approach to preventive care for women after menopause.
How Can We Help?
Dr. Danielle believes in empowering women with the knowledge and tools they need to take control of their health inside and out.
If you're in your 40s, 50s, or beyond and starting to notice changes in memory, focus, or physical strength, it might be time to start asking different questions. Are these signs simply “getting older,” or are they early clues that your body is asking for support?
Simple screening tools like SARC-F, along with cognitive assessments and a thorough medical review, can help identify your individual risk. Interventions may include:
Lifestyle support: weight-bearing exercise, resistance training, diet optimisation
Hormonal health review: considering MHT where appropriate
Brain health strategies: sleep hygiene, stress management, cognitive stimulation
Personalised screening and wellness planning
It’s never too early, or too late, to take a proactive stance on muscle and brain health.
Final Thoughts
While this latest research does not prove causation, it does shine a light on the value of integrated screening and prevention. As doctors, it reminds us to look beyond isolated symptoms and connect the dots between physical, hormonal, and cognitive wellbeing.
For women navigating perimenopause or post menopause, these findings reinforce that your strength is more than skin deep, it’s also about brain resilience, autonomy, and long-term vitality.
If you’d like to discuss your cognitive or physical health after menopause, book a consultation with Dr. Danielle at Aesthetic Astute. We take a personalised, holistic approach to women’s health and longevity.
📄 Download the SARC-F Questionnaire
Visit aestheticastute.com.au to read more about sarcopenia and how early screening can support long-term health. You're encouraged to complete the SARC-F questionnaire before your appointment to help guide your consultation.
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Disclaimer
This article is intended for general educational purposes only and does not constitute individual medical advice. Please consult your healthcare provider for personalised medical care and before making any changes to your health management plan.
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